O-Glycologue

Description: O-Glycologue is a simulator of the enzymes of O-linked glycosylation, developed and maintained by Andrew McDonald (School of Biochemistry & Immunology, Trinity College Dublin)

Getting started

Enter a glycan
Choose enzymes
React
or
Predict
Choose a starting substrate in GlycoForm*
Optionally, knock out one or more enzymes in silico
Present this glycan as a substrate to the enzymes of O-glycosylation
  
Predict the enzymes required to produce this glycan

*To select from a library of experimentally derived O-glycans, click here

Features

Source

Source code of the enzyme simulator implemented in Python 3 can be downloaded here

Publications

McDonald., A.G, Tipton, K.F. and Davey, G.P. (2016) A knowledge-based system for display and prediction of O-glycosylation network behaviour in response to enzyme knockouts. PLoS Comp. Biol. 12(4), e1004844. [doi: 10.1371/journal.pcbi.1004844]



Site last updated 2016-07-21