|Iterations:||– 1 +
|| Columns:||– 1 +
|| Style: CFG | UOXF
|GlcNAc limit:||– 4 +
|| Cell height:||– 1 +
Enter initial O-glycan
|Monoisotopic mass:||221.09 g/mol|
|Average mass:||221.208 g/mol
|Download image as: ||
Structure identifier: VT
IUPAC condensed name: GalNAc
Linear Code: ANa;
Enter a glycan into the text box as either an IUPAC name, or a structure identifier based on single-letter codes for monosaccharides,
according to the table below. Click the Draw
button to draw the structure; (optionally) click Select
to choose a knockout
set of enzymes to act on this structure; click React
to submit the currect structure to O-Glycologue as a
substrate of the enzymes of O-linked glycosylation. Click Predict
to run the enzyme simulator in reverse,
to discover a minimal set of enzymes required to produce the current glycan.
button generates a random walk through the predicted network in the biosynthetic direction.
(Example) Enter Galb1-4GlcNAcb1-6[Galb1-4GlcNAcb1-3Galb1-3]GalNAc
The anomericity of monosaccharides is implicit, based on the enzymes of O-glycosylation: L and Y are β-linked while f, S and V are assumed to be α-linked.
This can be overridden by placing a or b after the sugar symbol, thus La3 would draw an α1,3-linked galactose.
The size of networks produced in simulations can be limited by decreasing the maximum number of GlcNAc residues per glycan using the Control panel. The default value is set to 4.
|S||Neu5Ac||N-Acetylneuraminic acid (sialic acid)|
|a,b||α, β||Anomeric linkage type|